We conduct research to control micro and nano spaces using the unique properties of microfluidic device technology. For example, using the phenomenon of laminar flow in micro-space, we control differentiation factors in micro-space in a spatiotemporal manner to promote heterogeneous population differentiation of pluripotent cells (ES/iPS cells). We are also developing research on cell-cell interactions by creating microfluidic probes and other devices to stimulate only a portion of a cellular tissue population and examine the behavior of the surrounding area. We have also developed microfluidic devices that manipulate microparticles using the wonders of fluid mechanics, and have achieved single-cell manipulation, including fertilized eggs. We are also developing a tritium removal device that uses thermodynamics in addition to fluid mechanics to remove tritium, which is a problem in radioactively contaminated water.